Xenon Xe 133 and Breastfeeding

Summary of use during lactation

Information in this record refers to the use of xenon Xe 133 as a diagnostic agent. Because of its low systemic bioavailability after inhalation, the International Commission on Radiological Protection and other experts state breastfeeding need not be interrupted after administration of xenon Xe 133.[1-3]

Drug levels in milk and infant serum

Xenon 133 is a beta emitter with a physical half-life of 5.2 days, a photopeak of 81 keV, and beta-decay.[2] Because of the poor solubility of xenon Xe 133, the amount that enters the venous circulation after inhalation is negligible. The small amount of xenon Xe 133 gas that passes into the venous circulation returns rapidly to the lungs to be exhaled. Maternal Levels. Excretion of nonradioactive xenon in breastmilk was studied in 2 women who underwent about 1 hour of xenon anesthesia with a 65 to 69% inhaled xenon concentration. One mother consumed 8.3 L of xenon and the other had consumed 10 L during the procedure. Milk samples taken at 90 and 300 minutes after extubation contained no detectable xenon.[4] Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

References

1. StabinMG BreitzHB Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry. J Nucl Med 2000 41 863 73 10809203 PubMed
2. ParkerJA ColemanRE GradyE SNM practice guideline for lung scintigraphy 4.0. J Nucl Med Technol 2012 40 57 65 22282651 PubMed
3. MattssonS JohanssonL Leide SvegbornS Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions. Ann ICRP 2015 44 2 Suppl 319 21 26069086 PubMed
4. StuttmannR SchaferC HilbertP The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol 2010 10 1 20167123 PubMed