Cinnarizine and Breastfeeding

Summary of use during lactation

Cinnarizine is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. No information is available on the use of cinnarizine during breastfeeding. Expert opinion recommends that cinnarizine not be used in migraine prophylaxis in nursing mothers.[1-3] An alternate drug is preferred, especially while nursing a newborn or preterm infant.

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

(Antihistamine) Cetirizine, Desloratadine, Fexofenadine, Levocetirizine, Loratadine; (Migraine Prophylaxis) Divalproex, Erenumab, Metoprolol, Nortriptyline, Propranolol, Rimegepant, Topiramate, Valproic Acid

References

1. Pringsheim T, Davenport WJ, Mackie G, et al. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci 2012;39:S1-2.22683887 PubMed
2. Negro A, Delaruelle Z, Ivanova TA, et al. Headache and pregnancy: A systematic review. J Headache Pain 2017;18:106.29052046 PubMed
3. Davanzo R, Bua J, Paloni G, et al. Breastfeeding and migraine drugs. Eur J Clin Pharmacol 2014;70:1313-24.25217187 PubMed