Cinacalcet and Breastfeeding

Summary of use during lactation

No information is available on cinacalcet during breastfeeding. However, several newborn infants with disorders of calcium metabolism have been safely treated with cinacalcet.[1,2] Cinacalcet levels in milk are unlikely to be as high as the doses used in these case. If cinacalcet is required by the mother, it is not a reason to discontinue breastfeeding. Until more data are available, cinacalcet should only be used with careful infant monitoring during breastfeeding.

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

References

1. Leunbach TL, Hansen AT, Madsen M, et al. A novel case of neonatal severe hyperparathyroidism successfully treated with a type II calcimimetic drug. Bone Rep 2021;14:100761.33748353 PubMed
2. Karagöz K, Küçükali GK, Kavurt AS, et al. Experience with cinacalcet in neonatal severe hyperparathyroidism due to CASR mutation. Horm Res Paediatr 2024;97:282. doi:10.1159/000541189 PubMed