Thiethylperazine and Breastfeeding

Summary of use during lactation

Based on minimal excretion of other phenothiazine derivatives, it appears that occasional short-term use of thiethylperazine for the treatment of nausea and vomiting poses little risk to the breastfed infant.

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Phenothiazines cause galactorrhea in 26 to 40% of female patients.[1,2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3-5] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[6]

References

1. PolishukWZ KulcsarS Effects of chlorpromazine on pituitary function. J Clin Endocrinol Metab 1956 16 292 3 13286329 PubMed
2. HooperJHJr WelchVC ShackelfordRT Abnormal lactation associated with tranquilizing drug therapy. JAMA 1961 178 506 7 14448766 PubMed
3. TurkingtonRW Prolactin secretion in patients treated with various drugs: Phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med 1972 130 349 54 4560178 PubMed
4. TurkingtonRW Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab 1972 34 62 6 5061776 PubMed
5. MeltzerHY FangVS The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry 1976 33 279 86 1259521 PubMed
6. MaguireGA Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry 2002 63 Suppl 4 56 62 11913677 PubMed