Summary of use during lactation
No published information is available on the use of tadalafil during breastfeeding or on macitentan, which is in the combination product Opsumit. An alternate agent may be preferred. The manufacturer recommends that breastfeeding be discontinued during Opsumit therapy. Tadalafil should be completely eliminated from milk in 4 days. Macitentan and its active metabolite should be completely eliminated from milk in 10 days.
Drug levels in milk and infant serum
Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.
Effects in breastfed infants
Relevant published information was not found as of the revision date.
Effects on lactation and breastmilk
Relevant published information was not found as of the revision date.
Alternative drugs to consider
(Pulmonary Artery Hypertension) Bosentan, Epoprostenol, Nitric Oxide, Sildenafil, Treprostinil
Source: Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, NCBI Bookshelf. Check LactMed for the most recent revision.
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