Rifabutin and Breastfeeding

Summary of use during lactation

The amount of rifabutin in milk is insufficient to treat tuberculosis in the breastfed infant. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking rifabutin.[1-3] Monitor the infant for signs of liver toxicity. Breastmilk may be stained a brown-orange color.

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

Rifampin, Rifapentin

References

1. BlumbergHM BurmanWJ ChaissonRE American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 2003 167 603 62 12588714 PubMed
2. Anon. Treatment of tuberculosis. MMWR Recomm Rep 2003 52 1 77 12836625 PubMed
3. BartlettJG Guidelines section. Infect Dis Clin Pract 2002 11 467 71 10.1097/01.idc.0000086415.30743.15