Summary of use during lactation
No information is available on the use of palonosetron during breastfeeding. Until more data become available, palonosetron should be used with caution during breastfeeding. An alternate drug may be preferred. No information is available on the use of netupitant, which is the other component of the combination product Akynzeo, during breastfeeding. Because netupitant and its metabolites are more than 97% bound to plasma proteins, the amount in milk is likely to be low. Until more data become available, Akynzeo should be used with caution during breastfeeding. An alternate drug may be preferred.
Drug levels in milk and infant serum
Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.
Effects in breastfed infants
Relevant published information was not found as of the revision date.
Effects on lactation and breastmilk
Relevant published information was not found as of the revision date.
Alternative drugs to consider
Ondansetron
Source: Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, NCBI Bookshelf. Check LactMed for the most recent revision.
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