Orlistat and Breastfeeding

Summary of use during lactation

Orlistat is poorly absorbed orally, but a small amount has been detected in the milk of one woman. It is unlikely that orlistat will be absorbed by the infant in amounts that would adversely affect the breastfed infant. Because it inhibits the absorption of fat-soluble vitamins, mothers using it should take a multivitamin supplement at bedtime.

Drug levels in milk and infant serum

Maternal Levels. Orlistat was detected in the milk of one mother at a concentration of 2.3 ng/gram of milk. Because milk donors were anonymized in the study, it was not known if the mother was taking orlistat or at what dose.[1] Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

References

1. MusatadiM. Gonzalez-GayaB. IrazolaM. Multi-target analysis and suspect screening of xenobiotics in milk by UHPLC-HRMS/MS. Separations 2021 8 10.3390/separations8020014 PubMed