Lisuride and Breastfeeding

Summary of use during lactation

Lisuride is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. It lowers serum prolactin and is approved in some countries for lactation suppression. Some experts recommend lisuride as a safer alternative to bromocriptine for lactation suppression, but others recommend avoiding all lactation suppressants.[1,2] Data are insufficient recommend one treatment for lactation suppression over another.[3]

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Lisuride suppresses serum prolactin increases in a dose-related fashion.[4,5] Comparative studies have found lisuride comparable in efficacy to bromocriptine, although rebound lactation occurred in more patients treated with lisuride 0.4 mg daily than in those treated with bromocriptine 5 mg daily.[6,7] Rebound lactation appears to be less with a higher dose of 0.6 mg daily and with 15 days of therapy rather than 10 days.[8,9]

Alternative drugs to consider

(Hyperprolactinemia) Bromocriptine, Cabergoline

References

1. MarcellinL ChantryAA [Breast-feeding (part II): Lactation inhibition--Guidelines for clinical practice] J Gynecol Obstet Biol Reprod (Paris) 2015 44 1080 3 26527027 PubMed
2. Anon. Do not use drugs to delay the onset of lactation. Relieve the discomfort and wait. Prescrire Int 2012 32 918 20 23951598 PubMed
3. OladapoOT FawoleB Treatments for suppression of lactation. Cochrane Database Syst Rev 2012 9 CD005937 22972088 PubMed
4. HardtW Schmidt-GollwitzerM HorowskiR Suppression of lactation with lisuride. Gynecol Obstet Invest 1979 10 95 105 535777
5. De CeccoL VenturinePL RagniN Effect of lisuride on inhibition of lactation and serum prolactin. Br J Obstet Gynaecol 1979 86 905 8 508675
6. BohnetHG KatoK De MollH Prolactin stimulation tests: Different response patterns after bromocriptine, lisuride, and metergoline treatment of puerperal women. Obstet Gynecol 1988 71 53 5 3336541 PubMed
7. Van DamLJ RollandR Lactation-inhibiting and prolactin-lowering effect of lisuride and bromocriptine: A comparative study. Eur J Obstet Gynecol Reprod Biol 1981 12 323 30 7333409 PubMed
8. Sereno ColóJA Navarrete HortaMT [Inhibition of lactation with lisuride. Clinical evaluation] Ginecol Obstet Mex 1994 62 31 4 8168721 PubMed
9. StrahlHJ GoretzlehnerG StrahlS [Lactation inhibition with various dosages of lisuride--prolactin secretion and effectiveness] Zentralbl Gynakol 1985 107 300 3 4039514 PubMed