Fosfomycin and Breastfeeding

Summary of use during lactation

Limited information indicates that fosfomycin produces low levels in milk and is unlikely to be absorbed well by the infant because of the binding to calcium in the milk.[1] It is unlikely to cause any adverse effects in breastfed infants.

Drug levels in milk and infant serum

Maternal Levels. After 1 to 2 grams of fosfomycin given by injection, colostrum levels in 2 women were 4.8 mg/L and milk levels were 3.6 mg/L.[2,3] Further details of the studies were not given. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

Ciprofloxacin, Levofloxacin, Nitrofurantoin, Trimethoprim

References

1. Lebedevs T. Fosfomycin and breastfeeding. Aust Prescr 2020;43:113. doi:10.18773/austprescr.2020.04232921885 PubMed
2. Gallego A, Rodríguez A, Mata A. Fosfomycin: pharmacological studies. Drugs Today (Barc) 1974;10 (Suppl 1):161-8.
3. Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy 1977;23 Suppl 1:141-51.832510