Dyphylline and Breastfeeding

Summary of use during lactation

Dyphylline is no longer marketed in the US. Because of the relatively high levels in milk and a previous report with theophylline, occasional stimulant effects in infants should be anticipated in breastfed infants. No severe adverse reactions are expected. Amounts in milk can be minimized by avoiding breastfeeding for 3 to 4 hours after a dose.

Drug levels in milk and infant serum

Maternal Levels. After intramuscular administration of a single 5 mg/kg dose of dyphylline, peak milk levels usually occurred between 2 and 4 hours after the dose in 20 subjects. Peak milk levels averaged 24.3 mg/L.[1] Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

Albuterol, Aminophylline, Theophylline

References

1. Jarboe CH, Cook LN, Malesic I, et al. Dyphylline elimination kinetics in lactating women: Blood to milk transfer. J Clin Pharmacol 1981;21:405-10.7309903 PubMed