Cyclamate and Breastfeeding

Summary of use during lactation

Very little cyclamate enters breastmilk after maternal ingestion. However, some authors suggest that women may wish to limit the consumption of nonnutritive sweeteners while breastfeeding because their effect on the nursing infants are unknown.[1,2]

Drug levels in milk and infant serum

Maternal Levels. Forty-nine women consumed a beverage containing 60 mg of cyclamate. Normal and overweight women were about equally represented in the sample. Breastmilk samples were collected before the beverage and at 30, 60, 120, 180, 240, 300, and 360 minutes after the beverage. The average peak milk concentration was 2.56 mcg/L an occurred at 5 hours after the beverage.[3] Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

Aspartame

References

1. SylvetskyAC GardnerAL BaumanV Nonnutritive sweeteners in breast milk. J Toxicol Environ Health A 2015 78 1029 32 26267522 PubMed
2. RotherKI SylvetskyAC SchiffmanSS Non-nutritive sweeteners in breast milk: Perspective on potential implications of recent findings. Arch Toxicol 2015 89 2169 71 26462668 PubMed
3. StampeS Leth-MøllerM GreibeE Artificial sweeteners in breast milk: A clinical investigation with a kinetic perspective. Nutrients 2022 14 2635 35807817 PubMed