Summary of use during lactation
The amounts of bempedoic acid and its active metabolite are very low, but there is no published experience with bempedoic acid during breastfeeding. If a mother requires bempedoic acid, it is not a reason to discontinue breastfeeding. An alternate drug might be considered while nursing a newborn or preterm infant.
Drug levels in milk and infant serum
Maternal Levels. The manufacturer reports a study in which bempedoic acid 180 mg was given orally once daily for six consecutive days to 8 healthy lactating women. The estimated geometric mean bempedoic acid peak concentration in breastmilk was 118 mcg/L (range 79.6 to 251 mcg/L), occurring at a median of about 3 hours. The mean daily infant dose of bempedoic acid through breastmilk was approximately 0.03 mg/day (95% CI: 0.02; 0.05) or 0.012 mg/kg daily. The mean RID was approximately 0.5% of the maternal weight-adjusted dosage. Concentrations of ESP15228, the active metabolite, in milk were below the limit of quantitation (<20 mcg/L) in 7 of 8 subjects.[1] Infant Levels. Relevant published information was not found as of the revision date.
Effects in breastfed infants
Relevant published information was not found as of the revision date.
Effects on lactation and breastmilk
Relevant published information was not found as of the revision date.
Alternative drugs to consider
Cholestyramine, Colesevelam, Colestipol
Source: Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, NCBI Bookshelf. Check LactMed for the most recent revision.
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