Amphotericin B and Breastfeeding

Summary of use during lactation

Although no information exists on the milk excretion of amphotericin B, it is highly protein bound, has a large molecular weight, is virtually unabsorbed orally and has been use directly in the mouths of infants;[1] therefore, most reviewers consider it acceptable to use in nursing mothers.[2,3]

Drug levels in milk and infant serum

Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Relevant published information was not found as of the revision date.

Effects on lactation and breastmilk

Relevant published information was not found as of the revision date.

Alternative drugs to consider

(Systemic) Fluconazole; (Topical) Clotrimazole, Miconazole, Nystatin

References

1. HoppeJE Treatment of oropharyngeal candidiasis and candidal diaper dermatitis in neonates and infants: Review and reappraisal. Pediatr Infect Dis J 1997 16 885 94 9306485 PubMed
2. Mactal-HaafC HoffmanM KuchtaA Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact 2001 17 160 6 11847833 PubMed
3. IlettKF KristensenJH Drug use and breastfeeding. Expert Opin Drug Saf 2005 4 745 68 16011452 PubMed